abstract：:Omethoate is an organophosphate insecticide with high toxicity. The aim of this study was to investigate the protective effect of exogenous reduced glutathione (GSH) on omethoate-induced liver injury. Sprague-Dawley rats were randomly divided into three groups: control, OM (omethoate poisoning), and OM+GSH (omethoate ...

journal_title：Environmental toxicology and pharmacology

authors： Lu L,Wang X,Lang L,Fu F

更新日期：2010-11-01 00:00:00

abstract：:Permethrin and deltamethrin are insecticides used all over the world in agriculture to control pests. The aim of this work is to investigate the effects of subcutaneous permethrin and/or deltamethrin treatments on erythrocyte antioxidant enzymes activity in rats of different sex. The results obtained show that permeth...

journal_title：Environmental toxicology and pharmacology

authors： Chargui I,Falcioni ML,Cheikh HB,Gabbianelli R

更新日期：2010-09-01 00:00:00

abstract：:The neurotoxicity of monocrotophos (MCP) in the development of the serotonergic nervous system and swimming activity of larvae of the sea urchin, Hemicentrotus pulcherrimus, was examined. Lethal dose 50% of MCP was 43μg/ml. Overall morphology was not affected in larvae that received up to 30μg/ml of MCP soon after fer...

journal_title：Environmental toxicology and pharmacology

authors： Yao D,Ru S,Katow H

更新日期：2010-09-01 00:00:00

abstract：:Four extracts were prepared from the roots and leaves of Moricandia arvensis: root chloroform extract (ChlR), leaf chloroform extract (ChlL), root ethyl acetate extract (EAR) and leaf ethyl acetate extract (EAL). The genotoxic and antigenotoxic properties of these extracts were investigated by assessing the induction ...

journal_title：Environmental toxicology and pharmacology

authors： Skandrani I,Boubaker J,Bouhlel I,Limem I,Ghedira K,Chekir-Ghedira L

更新日期：2010-07-01 00:00:00

abstract：:This study was aimed at documenting the kinetic time courses of selenium (Se) in accessible biological matrices of volunteers following controlled applications of therapeutic shampoo containing Se, to better elucidate the mechanisms by which shampoo-Se accumulates in hair and hence estimate the contribution of this so...

journal_title：Environmental toxicology and pharmacology

authors： Noisel N,Bouchard M,Carrier G

更新日期：2010-05-01 00:00:00

abstract：:Exposure of HL-60 cells, a human myeloid cell line, to 500μM etomidate for 24h reduced cell viability and increased nitric oxide production and mitochondrial permeability transition pore (mPTP) opening. Preconditioning (1h) with 1μM etomidate 4h before exposure to the 500μM dose of etomidate attenuated those detriment...

journal_title：Environmental toxicology and pharmacology

authors： Zhang X,Xiong J,Jiao Y,Wang G,Zuo Z

更新日期：2010-05-01 00:00:00

abstract：:Taurine (TAU) has protective effects on experimental liver fibrosis. The present study investigates whether benefits of TAU are mediated through attenuation of oxidative and nitrosative stresses. Liver fibrosis was induced in male Wistar rats by simultaneous administration of iron (0.5%, w/w) and ethanol (6g/kg/day) f...

journal_title：Environmental toxicology and pharmacology

authors： Devi SL,Anuradha CV

更新日期：2010-03-01 00:00:00

abstract：:The effect of two fluorosurfactants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), on degranulation of rat basophilic leukemia RBL2H3 cells was investigated. PFOA and PFOS promoted IgE-mediated release of granule components of RBL2H3 cells at 10-300μM. At low concentrations (<30μM), the fluorosur...

journal_title：Environmental toxicology and pharmacology

authors： Yamaki K,Yoshino S

更新日期：2010-03-01 00:00:00

abstract：:Diclofenac is a nonsteroidal anti-inflammatory drug widely used in Mexico where it is sold over the counter. It enters water bodies through municipal and industrial discharges, posing a risk to water systems and aquatic organisms. Diclofenac-enriched artificial sediment was used to evaluate the toxicity of this pharma...

journal_title：Environmental toxicology and pharmacology

authors： Oviedo-Gómez DG,Galar-Martínez M,García-Medina S,Razo-Estrada C,Gómez-Oliván LM

更新日期：2010-01-01 00:00:00

abstract：:Glyphosate is the active ingredient and polyoxyethyleneamine, the major component, is the surfactant present in the herbicide Roundup formulation. The objective of this study was to analyze potential cytotoxicity of the Roundup and its fundamental substance (glyphosate). Albino male rats were intraperitoneally treated...

journal_title：Environmental toxicology and pharmacology

authors： El-Shenawy NS

更新日期：2009-11-01 00:00:00

abstract：:In an attempt to assess the intensity of environmental pollution in industrial zones of Kvarnerian Bay in Northern Adriatic Sea and the reactivity of Mytilus galloprovincialis to these changes, in this study we estimated the concentration of heavy metals at four locations in both sea-sediment and in the mussels. Furth...

journal_title：Environmental toxicology and pharmacology

authors： Mićović V,Bulog A,Kučić N,Jakovac H,Radošević-Stašić B

更新日期：2009-11-01 00:00:00

abstract：:We examined the association between non-occupational exposure to Mn and cognitive functions. The study was carried out in a mining district located in Hidalgo State, Mexico, with 288 adults. Air and blood Mn concentrations were determined, and neuropsychological tests were administered to explore cognitive functions a...

journal_title：Environmental toxicology and pharmacology

authors： Solís-Vivanco R,Rodríguez-Agudelo Y,Riojas-Rodríguez H,Ríos C,Rosas I,Montes S

更新日期：2009-09-01 00:00:00

abstract：:To investigate the effect of infrasound on the hippocampus-dependent spatial learning and memory as well as its underlying mechanisms, we measured the changes of cognitive abilities, brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) signal transduction pathway and neurogenesis in the hippocamp...

journal_title：Environmental toxicology and pharmacology

authors： Yuan H,Long H,Liu J,Qu L,Chen J,Mou X

更新日期：2009-09-01 00:00:00

abstract：:The impact of commonly used pesticides, endosulfan and deltamethrin, on the molecular stress level in black tiger shrimp Penaeus monodon, was assessed using classical oxidative stress biomarkers, protein carbonylation profiles, and levels of heat shock proteins. Results showed that 4 days exposure to 0.1 μg L(-1) delt...

journal_title：Environmental toxicology and pharmacology

authors： Dorts J,Silvestre F,Tu HT,Tyberghein AE,Phuong NT,Kestemont P

更新日期：2009-09-01 00:00:00

abstract：:It was evaluated the genotoxicity of glyphosate which up to now has heterogeneous results. The comet assay was performed in Hep-2 cells. The level of DNA damage in the control group (5.42±1.83 arbitrary units) for tail moment (TM) measurements has shown a significant increase (p<0.01) with glyphosate at a range concen...

journal_title：Environmental toxicology and pharmacology

authors： Mañas F,Peralta L,Raviolo J,Ovando HG,Weyers A,Ugnia L,Cid MG,Larripa I,Gorla N

更新日期：2009-07-01 00:00:00

abstract：:There is controversy as to whether low-level chronic exposure to methylmercury (MeHg) through maternal fish consumption may cause subtle effects in the developing child, owing in part to the potential ameliorating effects of beneficial seafood nutrients. The aim of the present investigation was to assess the ameliorat...

journal_title：Environmental toxicology and pharmacology

authors： Folven KI,Glover CN,Malde MK,Lundebye AK

更新日期：2009-07-01 00:00:00

abstract：:This study evaluated the effect of paraquat (PQ) and temperature on hematological parameters and nonspecific immune system of fish Colossoma macropomum (Cachama). Juveniles were used for all experiments. Fish were exposed to three temperatures (18, 28, 35°C) and 10mg/L PQ during 21 days (PQ LC(50) 96h was of 48.05mg/L...

journal_title：Environmental toxicology and pharmacology

authors： Salazar-Lugo R,Estrella A,Oliveros A,Rojas-Villarroel E,Villalobos de B L,Lemus M

更新日期：2009-05-01 00:00:00

abstract：:In the present study, two antioxidant components (polysaccharopeptide complex P(1-a) and condensed tannin P(1-b)) from rose (Rosa rugosa) flowers were each incubated with mouse erythrocytes to investigate their effect on erythrocyte superoxide dismutase (SOD), and catalase (CAT) activities. It was found that the activ...

journal_title：Environmental toxicology and pharmacology

authors： Jiang Y,Wong JH,Pi ZF,Ng TB,Wang CR,Hou J,Chen RR,Niu HJ,Liu F

更新日期：2009-05-01 00:00:00

abstract：:Epidemiological and experimental studies have demonstrated that cigarette smoking intensifies gastric ulceration. Although nicotine can act as an anxiolytic and antidepressant, its withdrawal may also lead to increased anxiety and depression. In order to associate the toxic actions of nicotine on gastric mucosa with a...

journal_title：Environmental toxicology and pharmacology

authors： Deniz M,Sahin HH,Tekin S,Yeşiller M,Ağaoğlu B,Cetinel S,Yeğen BÇ

更新日期：2009-03-01 00:00:00

abstract：:Ardipusilloside I, a triterpenoid saponin isolated from Ardisia pusilla A. DC, suppresses the growth of a variety of cancer cells, and has certain immunomodulative properties. Herein, we investigated its effect on glioblastoma cell line U87MG cells and primary cultured human glioblastoma cells, and examined the underl...

journal_title：Environmental toxicology and pharmacology

authors： Xiong J,Cheng G,Tang H,Zhen HN,Zhang X

更新日期：2009-03-01 00:00:00

abstract：:Grains of soybeans were treated with the recommended dose of fenitrothion insecticide, 5mg/kg, and double that dose, before storage for 30 weeks under ambient local conditions. During the storage period, the penetration and distribution of insecticide residues were studied. The amount of surface residues on stored soy...

journal_title：Environmental toxicology and pharmacology

authors： Farghaly M,El-Maghraby S

更新日期：2009-01-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are environmental contaminants found in the serum of human populations across the globe. A small set of sentinel PCB congeners (IUPAC# 101, 118, 138, 153, and 180) commonly sought in human serum are often used as markers of exposure. The Chicago Great Lakes cohort of pregnant African A...

journal_title：Environmental toxicology and pharmacology

authors： McGraw JE,Waller DP

更新日期：2009-01-01 00:00:00

abstract：:Essential oils from aerial parts of Piper aduncum (Matico) and Piper obliquum (Anis del Oriente) of ecuadorian origin were analyzed by GC-FID, GC-MS, (13)C NMR and their biological and pharmacological activities were assessed. Chemical composition proved to be unusually different from previous reports for safrole-rich...

journal_title：Environmental toxicology and pharmacology

authors： Guerrini A,Sacchetti G,Rossi D,Paganetto G,Muzzoli M,Andreotti E,Tognolini M,Maldonado ME,Bruni R

更新日期：2009-01-01 00:00:00

abstract：:Alteration of p53 protein level, and possible mutation of the p53 gene during carcinogenesis in mice exposed chronically (P) and transgenerationally to 2mg/ml aqueous extract of betel nut (AEBN) in drinking water, were studied. Exons 5 and 7 of the p53 gene were not mutated under both chronic and transgenerational exp...

journal_title：Environmental toxicology and pharmacology

authors： Choudhury Y,Sharan RN

更新日期：2009-01-01 00:00:00

abstract：:HC Orange No. 1 (HCO1, 2-nitro-4'-hydroxydiphenylamine) (CAS No. 54381-08-7) is used as a colorant in commercial hair dyes. The cytotoxicity of HCO1 to L929 mouse connective tissue fibroblast cells was determined by use of a battery of endpoints that included electron transport activity determined by the MTT assay and...

journal_title：Environmental toxicology and pharmacology

authors： Liu H,Chen J,Jiang J,Giesy JP,Yu H,Wang X

更新日期：2008-11-01 00:00:00

abstract：:The aim of this work was to evaluate the induction of protoporphyrins IX (PpIX) activity and superoxide anions (SO) in human leukocytes exposed to anthracene (ANT) and benzo(a)pyrene (B(a)P). The leukocyte LC(50)s for both hydrocarbons and the PpIX accumulation and SO overproduction were measured. The LC(50)s were 0.3...

journal_title：Environmental toxicology and pharmacology

authors： Uribe-Hernández R,Pérez-Zapata AJ,Vega-Barrita ML,Ramón-Gallegos E,Amezcua-Allieri MA

更新日期：2008-09-01 00:00:00

abstract：:N-Phenyl benzamides are potent antibacterial agents. They are active against both Gram-positive and Gram-negative bacteria. The Gram-positive bacteria have strong and thick cell wall while the Gram-negative bacterial have thin and permeable cell wall. The DFT based QSAR reveals that molecular weight and total energy s...

journal_title：Environmental toxicology and pharmacology

authors： Pasha FA,Muddassar M,Lee C,Cho SJ

更新日期：2008-09-01 00:00:00

abstract：:The recovery effect of chlorpyrifos (CPF) on antioxidant enzymes, locomotor behaviour and the target enzyme acetylcholinesterase (AChE) interaction were studied after exposure to 297μgL(-1) (LC(50) for 96h) in mosquito fish, Gambusia affinis. Activities of the antioxidant enzymes-superoxide dismutase, catalase, glutat...

journal_title：Environmental toxicology and pharmacology

authors： Kavitha P,Rao JV

更新日期：2008-09-01 00:00:00

abstract：:Paraquat (PQ) is a relatively safe and effective herbicide used all over the world. PQ is very toxic to all living organisms; and many cases of acute poisoning and death have been reported over the past decade. The main suggested potential mechanism for PQ toxicity is the production of superoxide radicals from the met...

journal_title：Environmental toxicology and pharmacology

authors： Mohammadi-Bardbori A,Ghazi-Khansari M

更新日期：2008-07-01 00:00:00

abstract：:Rats were given food flavor cinnamaldehyde (CNMA) orally by gavage at the dose of 2.14, 6.96, 22.62 and 73.5mg/kg body weight/day for 10, 30 and 90 days. Only the group of rats treated with CNMA at the dose 73.5mg/kg body weight/day for 90 days showed histological changes in the kidney followed by increased activities...

journal_title：Environmental toxicology and pharmacology

authors： Gowder SJ,Devaraj H

更新日期：2008-07-01 00:00:00

abstract：:Application of human antidotes against nerve agent intoxications to microcrustacean Daphnia magna (Crustacea, Cladocera) intoxicated by a nerve agent tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate) and their efficacy was investigated. It was found that antidotes can be successfully applied to intoxicated daphnids. ...

journal_title：Environmental toxicology and pharmacology

authors： Vesela S,Kuca K,Jun D

更新日期：2008-05-01 00:00:00

abstract：:Recent findings of high levels of predominantly lower chlorinated biphenyls in indoor and outdoor air open the question of possible health consequences. Lower chlorinated biphenyls are more readily metabolized to reactive and potentially harmful intermediates, acting as mutagens and cancer initiators. The goal of this...

journal_title：Environmental toxicology and pharmacology

authors： Maddox C,Wang B,Kirby PA,Wang K,Ludewig G

更新日期：2008-03-01 00:00:00

abstract：:The dechlorination of PCB, specifically the noncoplanar congener PCB 153, has been observed in the presence of a crude nitrate reductase extract from Medicago sativa leaves. These observations were further confirmed using a commercially available and pure nitrate reductase from Zea mays. The presence of nitrate reduct...

journal_title：Environmental toxicology and pharmacology

authors： Magee KD,Michael A,Ullah H,Dutta SK

更新日期：2008-03-01 00:00:00

abstract：:We have identified two most significant biomarker genes, CYP1A1 (69.81 up-regulation) and MT1K (14.66 up-regulation), showing highest overexpression at p-value <0.005. These were selected out of several hundred genes induced in vitro, using PCB exposed human liver (HepG2) cells. Over expression of the CYP1A1 (cytochro...

journal_title：Environmental toxicology and pharmacology

authors： Dutta SK,Ghosh S,De S,Hoffman EP

更新日期：2008-03-01 00:00:00

abstract：:Hydroquinone (HQ) is a myelotoxin that is found in many foods and formed through the metabolism of benzene. HQ is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. The aim of the current study was to explore the protective e...

journal_title：Environmental toxicology and pharmacology

authors： Ghaly IS,Said A,Abdel-Wahhab MA

更新日期：2008-01-01 00:00:00

abstract：:The present study examines the effects of PCN congeners (PCN50 and PCN66) on zebrafish embryos. The embryos were exposed to different concentrations (20, 30 and 50μg/l) of the respective congeners by dissolving 0.08% acetone. The following endpoints were investigated (mortality, hatching rate, abnormalities and heart ...

journal_title：Environmental toxicology and pharmacology

authors： Sişman T,Geyikoğlu F

更新日期：2008-01-01 00:00:00

abstract：:Diclofenac has recently been identified as a cause of the widespread vulture decline on the Indian subcontinent. Although the clinical signs and pathology have been described, the pathophysiology of toxicity remains unexplained. In the following study we attempt to validate the domestic fowl as a model, to allow for t...

journal_title：Environmental toxicology and pharmacology

authors： Naidoo V,Duncan N,Bekker L,Swan G

更新日期：2007-11-01 00:00:00

abstract：:The aliphatic ether 1,6-dimethoxyhexane (DMH) was previously identified as a testicular toxicant. Testis protein extracts from control and DMH-treated rats were subjected to two-dimensional gel electrophoresis for comparison of protein expression profiles. MALDI-ToF peptide mass fingerprinting of differentially expres...

journal_title：Environmental toxicology and pharmacology

authors： Pelletier G,Masson S,Wang YL,Wade MG,Mohottalage S,Kumarathasan P,Vincent R,Poon R,Chu I

更新日期：2007-09-01 00:00:00

abstract：:Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is a chlorinated phenolic antibacterial compound found as an active ingredient in many personal care and household products. The structural similarity of triclosan to thyroid hormones and recent studies demonstrating activation of the human pregnane X receptor (PXR) a...

journal_title：Environmental toxicology and pharmacology

authors： Crofton KM,Paul KB,Devito MJ,Hedge JM

更新日期：2007-09-01 00:00:00

abstract：UNLABELLED:The present research introduces the method of Production of M2000 (β-d-mannuronic acid) and its therapeutic effect on experimental model of nephritis. M2000 was produced using enzymatic and chemical procedure on prepared alginate from Pseudomonas fluorescens. The experimental glomerulonephritis was induced i...

journal_title：Environmental toxicology and pharmacology

authors： Mirshafiey A,Rehm B,Abhari RS,Borzooy Z,Sotoude M,Razavi A

更新日期：2007-07-01 00:00:00